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Ketoacidosis and fluidsThe debate around fluid resuscitation and maintenance in DKA has been smouldering for years, the recent, large PECARN FLUID buy viagra cvs trial providing some guidance, but, not drawing a line under all the issuesIn the light of the study, revisiting the arguments is useful and a group of three papers re-open the discussion. The catalyst on this occasion has been the publication of new British Society of Paediatric Endocrinology (BSPED) guidance, recommendations which leave ultimate decision making to the individual clinician but in broad terms suggest an initial resuscitation bolus (of 10 mL/kg) to all children. Our first correspondent, John Lillie on behalf of the South Thames Retrieval Service whose policy has been restrictive buy viagra cvs since 2008 after three deaths from DKA associated cerebral oedema argues that degree of dehydration (an agreed moot point by all parties) is all too easily overestimated particularly when capillary refill time (prolonged by hypocapnoea inherent to ketosis) is used to make the assessment.

Neil Wright on behalf of BPSED argues that once initial resuscitation is completed there is little difference philosophically between the two approachesThe physiology, science and moot points are weighed up in Robert Tasker’s editorial in which one bystander in recent debate, the rate of insulin infusion is also revisited, a lower exposure causing less rapid shifts in osmotic pressure and (theoretically) less risk of cerebral oedema. Here we come full circle in that the number of children developing this complication is so low that even a trial as large as FLUID is potentially underpowered. See pages 1019, 1020 buy viagra cvs and 917Perinatal encephalopathyThe dangers of over-diagnosis of a vague entity are highlighted in Mustayev’s systematic review.

The term perinatal encephalopathy (PE) (sometimes also called the ‘syndrome of intracranial hypertension’) was coined by a Russian paediatrician Iurii Iakunin in the 1970s referring to a range of signs and symptoms thought to be attributable to a perinatal insult, mediated by a rise in intracranial pressure. The notion buy viagra cvs was admirable, but the group of disorders inevitably heterogenous. As the term became more widely used in Eastern European countries, it was sometimes applied to infants and children with transient signs and no discernable pathology.

The nomenclature was (paradoxically) reinforced by the lack of a unifying diagnostic test. The label being at the buy viagra cvs discretion of the paediatrician or paediatric neuropathologist, to which many of these infants were referred. Diagnoses result in treatments and wide range of agents had been used on occasions.

Anticonvulsants, mineral and metabolic supplements, diuretics, cattle-derived neuropeptides, vasoactive agents, psychostimulants, and physical therapies. The issue of the Perinatal Encephalopathy Syndrome has long been on the radar of buy viagra cvs the WHO, and was the subject of a meeting in St Petersburg in 2007, at which many positive signs of reform were seen. This review shows further change, but some areas of continuing concern related to the diagnosis which still appears to be applied in some areas.

These potential harms are both direct and indirect and include the failure buy viagra cvs to diagnose other disorders. Unnecessary follow-up appointments and diagnostic procedures. The development of the vulnerable child syndrome.

And even deferral of buy viagra cvs vaccinations. See page 921After sudden infant deathSUDI is a rare event and a second death in a subsequent child extremely unusual, but to date there has been little data to quantify the recurrence risk and counsel parents. Garstang’s analysis of the Care of the Next Infant database from 2000 to 2015 provides some answers.

Over this period, 6608 live-born infants were buy viagra cvs registered. 171 were first-born infants to mothers whose male partners had previously had an unexplained infant death. 29 unexpected infant deaths following the index buy viagra cvs death occurred in 26 families, 23 with 2 deaths and 3 with three deaths.

The second SUDI rate was estimated as 3.93 per 1000 live births and the third as 115 per 1000 live births. The findings should not, though, engender complacency as there have in the past been convictions for homicide. The risk of repeat SUDI in a family is still 10 times that of the general population, a reflection of inherent genetic risks as well buy viagra cvs as environmental factors such as maternal smoking and unsafe sleeping.

CONI cannot address intrinsic risk factors, but these are very vulnerable families who need comprehensive care and support packages to help them understand safe sleeping, address mental health problems and enhance their parenting capacity. See page 945Emergency steroids and asthma prophylaxisIn a neat and salutary reminder of the reason buy viagra cvs some children reach the stage of requiring rescue oral corticosteroids (OCS) at routine clinic appointments, Willson reviews experience from a quarternary respiratory department with respect to adherence prescribed prophylaxis. In the series 25 children received 32 courses of OCS.

For those episodes with full data, uptake of prescriptions for inhaled corticosteroid prophylaxis, the median uptake over the previous 6 months was only 33% and in only 29% episodes was uptake ≥75% of that prescribed So, rather than just prescribe the emergency course and ascribe it to bad luck or bad asthma… maybe check on adherence. This and buy viagra cvs related themes are explored in Ian Sinha’s Viewpoint exploration of the national respiratory audit database. See pages 993 and 910Monitoring inflammatory bowel diseaseEqually pragmatic is the issue with calprotectin stability described by Haisma.

Stool calprotectin is pivotal in the diagnosis, monitoring of and to treatment modifications in IBD. Often a sample will buy viagra cvs be taken in the home and dropped off at the lab or sent by post having spent time at room temperature in the interim rather than the recommended 4 C. The fall in levels is so great (35% and 46% in extraction buffer) that disease activity will inevitably be underestimated and treatment not increased appropriately.

So, before reducing immune modulating treatment immediately, check how the sample buy viagra cvs travelled before analysis and, if in any doubt, recheck making any changes. See page 996Two letters in the journal focus on the volume of intravenous fluid to be used during resuscitation and early management of paediatric patients presenting with diabetic ketoacidosis (DKA).1 2 The correspondence encapsulates an important debate about intravenous fluids and risk of morbidities, such as cerebral oedema, and provides us with the range in contemporary opinions in the UK.Lillie et al1 use their insights from the South Thames Retrieval service (STRS) and its 20 referring district general hospitals to highlight a concern about the new British Society for Paediatric Endocrinology and Diabetes (BSPED) guideline3 and integrated care pathway4 for the management of DKA. The authors have a network of emergency practice, and they imply that the new emphasis by the BSPED on permissive rather than restrictive (ie, reduced volume rules) intravenous fluids will be disruptive to the measures that they have taken since dealing with three cerebral oedema deaths in their region.

Wright and Thomas2 have responded on behalf of buy viagra cvs the BSPED DKA interest group. They emphasise the importance of adequate intravenous fluid resuscitation in limiting morbidity. They also provide an instructive table2 showing fluid resuscitation and rehydration volumes used in a number of protocols, including that of STRS and the new BSPED approach.

The main differences come down to the estimate of fluid deficit, the use of an intravenous fluid bolus at presentation and the calculation of maintenance buy viagra cvs fluid requirements.The STRS approach assumes a 10% fluid deficit in all patients with DKA at presentation, versus the new BSPED guideline’s use of three levels in estimated fluid deficit based on severity of acidosis (ie, pH >7.2, 5%. PH 7.1 to 7.2, 7%. And pH <7.1, 10%) buy viagra cvs.

In the STRS approach, an intravenous fluid bolus of 10 mL/kg normal saline (NS) is reserved for patients in shock. In contrast, the new BSPED guideline recommends that all patients with DKA receive an intravenous bolus of 10 mL/kg NS, with an extra 10 mL/kg NS (20 mL/kg in total) for those in shock. Last, in the STRS protocol, the 10% fluid deficit is repaired over 48 hours by adding the buy viagra cvs volume to restrictive or so-called reduced volume rules for maintenance intravenous requirements and for body weight (ie, up to 10 kg, 2 mL/kg/hour.

10–14 kg, 1 mL/kg/hour and >40 kg, fixed volume 40 mL/hr). The new BSPED guideline also recommends replacing the presumed fluid deficit over 48 hours, but this hourly volume is added to standard (and higher than reduced volume rules) maintenance intravenous fluids.4 5Now, add to this mixture of opinions, the UK National Institute for Health and Care buy viagra cvs Excellence (NICE) latest updated pathway for DKA in children and young people.6 Like the new BSPED guideline, NICE also estimates fluid deficit based on severity of acidosis. However, severity of fluid deficit is dichotomised to 5% or 10% based on whether pH is above or below 7.1, respectively.

Like the STRS approach, there is no routine use of an intravenous NS fluid bolus in severe DKA. Last, like the STRS approach the buy viagra cvs estimated fluid deficit is repaired over 48 hours by adding the hourly volume to maintenance requirement calculated using reduced volume rules.How can there be such variance in opinion and recommendations and what should we do?. To be fair, the new BSPED guideline3 was only ever ‘… an interim recommendation pending the publication of the future NICE review.’ But, more importantly, the BSPED website acknowledges that the onus for decision-making remains with the clinician.

A similar stance on responsibility of guideline users is also taken by NICE.The new information that seems to have influenced the BSPED and the NICE updates on DKA is the Pediatric Emergency Care Applied Research Network (PECARN) clinical trial of fluid infusion rates for paediatric DKA (FLUID trial).7 It is worth re-reading the paper and its protocol and supplementary appendix, in particular have a look at Figure S1 on compliance to assigned fluid rate. The bottom buy viagra cvs line of the FLUID trial is that neither the rate of administration (fast vs slow repair) nor the sodium chloride content (NS vs 0.45% saline) of intravenous fluids significantly influenced neurological outcomes. Wright and Thomas2 show in their table that the difference between fast and slow repair in the trial was complex and not only included a difference in timing of fluid-deficit repair (ie, fast with 50% repair in first 12 hours followed by 50% repair in next 24 hours vs slow repair evenly distributed over 48 hours).

It also involved differences in presumed buy viagra cvs fluid deficit (10% vs 5%) and use of intravenous NS boluses (20 mL/kg vs 10 mL/kg). Close review of the compliance to assigned fluid rate in the FLUID trial (see Supplemental Figure S17) shows that actual fluid received by patients in the fast and slow repair groups are similar to those suggested by the BSPED and STRS/NICE, respectively. If there is no difference in neurological outcome, does the difference in fluid strategy really matter, as each of our correspondents argue?.

To attempt to answer this question buy viagra cvs we have to look at two key details of the FLUID trial. The first is that of the 1389 patients undergoing randomisation, 1263 (91%) had Glasgow Coma Scale (GCS) score 15, 99 (7%) had GCS score 14 and 28 (2%) had GCS score <14. In essence, the test of fast versus slow fluid strategy is strongly influenced by patients with DKA who are fully awake at presentation.

Both of our correspondents1 2 acknowledge that patients buy viagra cvs with altered mental state raise concern, although their approaches differ—on this matter we have no answer from the FLUID trial. The other detail to consider is that the uniformly used standard insulin infusion rate (0.1 U/kg/hour) differs from the dosing range (0.05 to 0.1 U/kg/hour) used in UK practice.3 4 6 One theoretical aim of low-dose insulin (0.05 U/kg/hour)8 9 is to avoid too rapid decrease in serum glucose concentration (ie, >5.5 mmol/L/hour), with consequent too rapid change in serum osmolarity, which may increase the risk of cerebral oedema.10 11 Does this idea mean that the low-dose insulin strategy enables better tolerance of fast-fluid repair rate, with low risk of morbidity?. Impossible to buy viagra cvs answer.

As we see from the FLUID trial, such a proposition—with an outcome of brain injury in less than 1% of DKA episodes—is likely untestable in a future sufficiently powered clinical trial.Taking all the above together, there is clearly a need to realign the variance in DKA fluid management reflected in the STRS,1 BSPED2–4 and NICE6 approaches. Even though we have gold standard clinical information from the PECARN DKA FLUID trial,7 the relevance of that information to all paediatric patients presenting with DKA needs careful consideration. Which means that clinicians still buy viagra cvs need to exercise judgement in individual situations.

Finally, the letter by Lillie et al1 also reminds us of the value of systems of care. Their hub-and-spoke network for emergency DKA care is not just about adopting latest recommendations but is also tasked with bringing about any necessary knowledge-to-action change (see the table and figure 2 as responses to three cerebral oedema DKA deaths),1 a process called implementation science.12.

Ketoacidosis and fluidsThe debate around fluid resuscitation and maintenance in DKA has been smouldering for years, the Livalo discount recent, large PECARN FLUID trial providing some guidance, but, not drawing a line under all the issuesIn the light of the study, revisiting the arguments is useful and a group of can i buy viagra online three papers re-open the discussion. The catalyst on this occasion has been the publication of new British Society of Paediatric Endocrinology (BSPED) guidance, recommendations which leave ultimate decision making to the individual clinician but in broad terms suggest an initial resuscitation bolus (of 10 mL/kg) to all children. Our first correspondent, John Lillie on behalf of the South Thames Retrieval Service whose policy has been restrictive since 2008 after three deaths from DKA associated cerebral oedema argues that degree of dehydration (an agreed moot point by all parties) is all too easily overestimated particularly when capillary refill time (prolonged by hypocapnoea can i buy viagra online inherent to ketosis) is used to make the assessment.

Neil Wright on behalf of BPSED argues that once initial resuscitation is completed there is little difference philosophically between the two approachesThe physiology, science and moot points are weighed up in Robert Tasker’s editorial in which one bystander in recent debate, the rate of insulin infusion is also revisited, a lower exposure causing less rapid shifts in osmotic pressure and (theoretically) less risk of cerebral oedema. Here we come full circle in that the number of children developing this complication is so low that even a trial as large as FLUID is potentially underpowered. See pages 1019, 1020 and 917Perinatal encephalopathyThe dangers of over-diagnosis of a vague entity are highlighted can i buy viagra online in Mustayev’s systematic review.

The term perinatal encephalopathy (PE) (sometimes also called the ‘syndrome of intracranial hypertension’) was coined by a Russian paediatrician Iurii Iakunin in the 1970s referring to a range of signs and symptoms thought to be attributable to a perinatal insult, mediated by a rise in intracranial pressure. The notion was admirable, but the group of disorders inevitably can i buy viagra online heterogenous. As the term became more widely used in Eastern European countries, it was sometimes applied to infants and children with transient signs and no discernable pathology.

The nomenclature was (paradoxically) reinforced by the lack of a unifying diagnostic test. The label being at the discretion of the paediatrician or paediatric neuropathologist, to which many of these infants were can i buy viagra online referred. Diagnoses result in treatments and wide range of agents had been used on occasions.

Anticonvulsants, mineral and metabolic supplements, diuretics, cattle-derived neuropeptides, vasoactive agents, psychostimulants, and physical therapies. The issue of can i buy viagra online the Perinatal Encephalopathy Syndrome has long been on the radar of the WHO, and was the subject of a meeting in St Petersburg in 2007, at which many positive signs of reform were seen. This review shows further change, but some areas of continuing concern related to the diagnosis which still appears to be applied in some areas.

These potential harms are both direct and indirect and include the can i buy viagra online failure to diagnose other disorders. Unnecessary follow-up appointments and diagnostic procedures. The development of the vulnerable child syndrome.

And even can i buy viagra online deferral of vaccinations. See page 921After sudden infant deathSUDI is a rare event and a second death in a subsequent child extremely unusual, but to date there has been little data to quantify the recurrence risk and counsel parents. Garstang’s analysis of the Care of the Next Infant database from 2000 to 2015 provides some answers.

Over this period, can i buy viagra online 6608 live-born infants were registered. 171 were first-born infants to mothers whose male partners had previously had an unexplained infant death. 29 unexpected infant deaths following the index death occurred in 26 families, 23 with 2 deaths and 3 with three deaths can i buy viagra online.

The second SUDI rate was estimated as 3.93 per 1000 live births and the third as 115 per 1000 live births. The findings should not, though, engender complacency as there have in the past been convictions for homicide. The risk of repeat SUDI in a family is still 10 times can i buy viagra online that of the general population, a reflection of inherent genetic risks as well as environmental factors such as maternal smoking and unsafe sleeping.

CONI cannot address intrinsic risk factors, but these are very vulnerable families who need comprehensive care and support packages to help them understand safe sleeping, address mental health problems and enhance their parenting capacity. See page 945Emergency steroids and asthma prophylaxisIn a neat and salutary can i buy viagra online reminder of the reason some children reach the stage of requiring rescue oral corticosteroids (OCS) at routine clinic appointments, Willson reviews experience from a quarternary respiratory department with respect to adherence prescribed prophylaxis. In the series 25 children received 32 courses of OCS.

For those episodes with full data, uptake of prescriptions for inhaled corticosteroid prophylaxis, the median uptake over the previous 6 months was only 33% and in only 29% episodes was uptake ≥75% of that prescribed So, rather than just prescribe the emergency course and ascribe it to bad luck or bad asthma… maybe check on adherence. This and related themes are explored in can i buy viagra online Ian Sinha’s Viewpoint exploration of the national respiratory audit database. See pages 993 and 910Monitoring inflammatory bowel diseaseEqually pragmatic is the issue with calprotectin stability described by Haisma.

Stool calprotectin is pivotal in the diagnosis, monitoring of and to treatment modifications in IBD. Often a sample will be taken in the home and dropped off at the lab or can i buy viagra online sent by post having spent time at room temperature in the interim rather than the recommended 4 C. The fall in levels is so great (35% and 46% in extraction buffer) that disease activity will inevitably be underestimated and treatment not increased appropriately.

So, before reducing immune modulating treatment immediately, check how the sample travelled before analysis can i buy viagra online and, if in any doubt, recheck making any changes. See page 996Two letters in the journal focus on the volume of intravenous fluid to be used during resuscitation and early management of paediatric patients presenting with diabetic ketoacidosis (DKA).1 2 The correspondence encapsulates an important debate about intravenous fluids and risk of morbidities, such as cerebral oedema, and provides us with the range in contemporary opinions in the UK.Lillie et al1 use their insights from the South Thames Retrieval service (STRS) and its 20 referring district general hospitals to highlight a concern about the new British Society for Paediatric Endocrinology and Diabetes (BSPED) guideline3 and integrated care pathway4 for the management of DKA. The authors have a network of emergency practice, and they imply that the new emphasis by the BSPED on permissive rather than restrictive (ie, reduced volume rules) intravenous fluids will be disruptive to the measures that they have taken since dealing with three cerebral oedema deaths in their region.

Wright and Thomas2 have responded on behalf of the BSPED can i buy viagra online DKA interest group. They emphasise the importance of adequate intravenous fluid resuscitation in limiting morbidity. They also provide an instructive table2 showing fluid resuscitation and rehydration volumes used in a number of protocols, including that of STRS and the new BSPED approach.

The main differences come down to the estimate of fluid deficit, the use of an intravenous fluid bolus at presentation and the calculation of maintenance fluid requirements.The STRS approach assumes a 10% fluid deficit in all patients with DKA at presentation, versus the new BSPED guideline’s use of can i buy viagra online three levels in estimated fluid deficit based on severity of acidosis (ie, pH >7.2, 5%. PH 7.1 to 7.2, 7%. And pH <7.1, 10%) can i buy viagra online.

In the STRS approach, an intravenous fluid bolus of 10 mL/kg normal saline (NS) is reserved for patients in shock. In contrast, the new BSPED guideline recommends that all patients with DKA receive an intravenous bolus of 10 mL/kg NS, with an extra 10 mL/kg NS (20 mL/kg in total) for those in shock. Last, in the STRS protocol, the 10% fluid deficit is repaired over 48 hours by adding the volume to restrictive or so-called reduced volume rules for maintenance intravenous requirements and for body weight (ie, up can i buy viagra online to 10 kg, 2 mL/kg/hour.

10–14 kg, 1 mL/kg/hour and >40 kg, fixed volume 40 mL/hr). The new BSPED guideline also recommends replacing the presumed can i buy viagra online fluid deficit over 48 hours, but this hourly volume is added to standard (and higher than reduced volume rules) maintenance intravenous fluids.4 5Now, add to this mixture of opinions, the UK National Institute for Health and Care Excellence (NICE) latest updated pathway for DKA in children and young people.6 Like the new BSPED guideline, NICE also estimates fluid deficit based on severity of acidosis. However, severity of fluid deficit is dichotomised to 5% or 10% based on whether pH is above or below 7.1, respectively.

Like the STRS approach, there is no routine use of an intravenous NS fluid bolus in severe DKA. Last, like can i buy viagra online the STRS approach the estimated fluid deficit is repaired over 48 hours by adding the hourly volume to maintenance requirement calculated using reduced volume rules.How can there be such variance in opinion and recommendations and what should we do?. To be fair, the new BSPED guideline3 was only ever ‘… an interim recommendation pending the publication of the future NICE review.’ But, more importantly, the BSPED website acknowledges that the onus for decision-making remains with the clinician.

A similar stance on responsibility of guideline users is also taken by NICE.The new information that seems to have influenced the BSPED and the NICE updates on DKA is the Pediatric Emergency Care Applied Research Network (PECARN) clinical trial of fluid infusion rates for paediatric DKA (FLUID trial).7 It is worth re-reading the paper and its protocol and supplementary appendix, in particular have a look at Figure S1 on compliance to assigned fluid rate. The bottom can i buy viagra online line of the FLUID trial is that neither the rate of administration (fast vs slow repair) nor the sodium chloride content (NS vs 0.45% saline) of intravenous fluids significantly influenced neurological outcomes. Wright and Thomas2 show in their table that the difference between fast and slow repair in the trial was complex and not only included a difference in timing of fluid-deficit repair (ie, fast with 50% repair in first 12 hours followed by 50% repair in next 24 hours vs slow repair evenly distributed over 48 hours).

It also involved differences in presumed fluid deficit (10% vs 5%) and use of intravenous can i buy viagra online NS boluses (20 mL/kg vs 10 mL/kg). Close review of the compliance to assigned fluid rate in the FLUID trial (see Supplemental Figure S17) shows that actual fluid received by patients in the fast and slow repair groups are similar to those suggested by the BSPED and STRS/NICE, respectively. If there is no difference in neurological outcome, does the difference in fluid strategy really matter, as each of our correspondents argue?.

To attempt to answer this question we have to look at can i buy viagra online two key details of the FLUID trial. The first is that of the 1389 patients undergoing randomisation, 1263 (91%) had Glasgow Coma Scale (GCS) score 15, 99 (7%) had GCS score 14 and 28 (2%) had GCS score <14. In essence, the test of fast versus slow fluid strategy is strongly influenced by patients with DKA who are fully awake at presentation.

Both of our correspondents1 2 acknowledge that patients can i buy viagra online with altered mental state raise concern, although their approaches differ—on this matter we have no answer from the FLUID trial. The other detail to consider is that the uniformly used standard insulin infusion rate (0.1 U/kg/hour) differs from the dosing range (0.05 to 0.1 U/kg/hour) used in UK practice.3 4 6 One theoretical aim of low-dose insulin (0.05 U/kg/hour)8 9 is to avoid too rapid decrease in serum glucose concentration (ie, >5.5 mmol/L/hour), with consequent too rapid change in serum osmolarity, which may increase the risk of cerebral oedema.10 11 Does this idea mean that the low-dose insulin strategy enables better tolerance of fast-fluid repair rate, with low risk of morbidity?. Impossible to can i buy viagra online answer.

As we see from the FLUID trial, such a proposition—with an outcome of brain injury in less than 1% of DKA episodes—is likely untestable in a future sufficiently powered clinical trial.Taking all the above together, there is clearly a need to realign the variance in DKA fluid management reflected in the STRS,1 BSPED2–4 and NICE6 approaches. Even though we have gold standard clinical information from the PECARN DKA FLUID trial,7 the relevance of that information to all paediatric patients presenting with DKA needs careful consideration. Which means can i buy viagra online that clinicians still need to exercise judgement in individual situations.

Finally, the letter by Lillie et al1 also reminds us of the value of systems of care. Their hub-and-spoke network for emergency DKA care is not just about adopting latest recommendations but is also tasked with bringing about any necessary knowledge-to-action change (see the table and figure 2 as responses to three cerebral oedema DKA deaths),1 a process called implementation science.12.

Home made viagra

Jan http://www.em-gliesberg-strasbourg.ac-strasbourg.fr/?page_id=187 home made viagra. 31, 2022 -- This past October, Chris Habitz, the owner of Your CBD Store in Burbank, CA, began getting more requests from customers for CBD products with delta -8 THC, also known as "diet weed" or "marijuana-lite."Many were seniors, he says, asking for the products to soothe pain and avoid opioids, as well as to avoid the high" from using marijuana.Citing the potential for addiction to prescription painkillers, Habitz says, "a lot them are scared."Others asked for the delta-8 products to soothe anxiety during the viagra. So, Habitz ordered three times as many of home made viagra the delta-8 products as usual -- and sold them. The demand has remained. And, he home made viagra says, “it hasn't peaked."On the other side of the country, Bison Botanics in Buffalo, NY, which sells a range of CBD products, began seeing high demand for delta-8 products at the start of 2021, says Sean Connors, Bison's vice president.

"By the end of 2021, it was 65% of sales," he says. Delta-8 THC home made viagra (tetrahydrocannabinol) is one of more than 100 compounds, or cannabinoids, found in the Cannabis sativa plant. Delta-8 is found in marijuana and in hemp-derived CBD, but in trace amounts, much lower than the levels of delta-9 THC found in marijuana that produces the “high."Delta-8 THC products, sold in vape pen cartridges and as oils, gummies, candies, and other edibles, are widely available at CBD stores, convenience stores, gas stations, dispensaries, and online. Besides pain and anxiety relief, promoters say it can boost appetite, help you sleep better, combat nausea and vomiting, and help with relaxation.It's difficult to pinpoint nationwide sales figures, with many companies not reporting publicly, says Adam Koh, editorial director of Cannabis Benchmarks &. Hemp Benchmarks, home made viagra which provides industry data."I think it's safe to say that sales of delta-8 THC and similar products in the U.S.

Likely generated several hundred million dollars in 2021. These products began to emerge around summer 2020, and I believe sales were substantially smaller that year."Online searches for delta-8 THC rose dramatically from 2019 to 2020, say researchers from home made viagra the University of California, San Diego, who reported that interest was especially high in U.S. States that restricted delta-9 THC use. Is It Legal, or home made viagra Is There a Loophole?. No one debates delta-8 THC's popularity.

But is it legal?. As sales have risen, so have debates home made viagra about its legality.The boom in delta-8 products began shortly after the passage of the Farm Bill, also known as the Agriculture Improvement Act of 2018. This act removed hemp and its byproducts (but not cannabis) from the federal list of Schedule I controlled substances. It legalizes the production and sale of CBD products as long as they have less home made viagra than 0.3% of THC. Many advocates of delta-8 CBD products point out that the Farm Bill fails to mention delta-8, so the products are on legal firm ground.

Not everyone agrees."People read that Farm Bill and said, 'Wait, delta-8 and delta-10 [another cannabinoid] are not mentioned,'" says researcher Shanna Babalonis, PhD, home made viagra an assistant professor of behavioral science at the University of Kentucky. "Let's start marketing that stuff."Here's the problem, says Paul Armentano, deputy director of the National Organization for the Reform of Marijuana Laws, or NORML. The Farm Bill language does make a legal distinction between “naturally occurring constituents" and "synthetically derived" ones. He points to how the Drug Enforcement home made viagra Administration defined the issue in the Farm Bill in 2020. Under that explanation, "if you extract cannabinoids present in the industrial hemp plant, products from those are legal under the Farm Bill," he says.If delta-8 were simply extracted, fine.

But "that is not what these home made viagra [delta-8] products are."The natural amount of delta-8-THC in hemp is low, but concentrated amounts can be created from CBD in a lab. Large quantities of delta-8 THC “are being chemically synthesized from excess CBD that has been derived from hemp plants," Babalonis says.And all synthetic tetrahydrocannabinols are still Schedule I controlled substances, just as marijuana is, according to language in the Farm Bill, Armentano says. The Farm home made viagra Bill also specifies that hemp can't contain more than 0.3% of THC, and observers say many delta-8 products contain higher levels, making the products intoxicating.Delta-8. Nicer and Milder, or Potentially Hazardous?. While some debate whether delta-8 THC is legal, researchers say it has been called “delta-9's younger, nicer sibling." That's what one home made viagra respondent told researchers Jessica Kruger, PhD, a clinical assistant professor of community health and health behavior at the University at Buffalo, and Daniel J.

Kruger, PhD, an investigator at the Population Studies Center at the University of Michigan. After the husband-wife research team polled more than 500 people from 38 states and asked them to compare delta-8 to cannabis, they concluded that delta-8 appears to have positive qualities and may be a way to reduce harm and negative reactions, compared to marijuana. Respondents said delta-8 THC had all the benefits of cannabis and fewer bad effects.In home made viagra their study, 71% of the users reported “a lot or a great deal” of relaxation, and 68% said they’d had euphoria. More than half got relief from pain. But they also reported some of the same unwanted effects with delta-8 as with marijuana, with 81% having moderate to “a lot of" skewed thinking, such as a hard home made viagra time concentrating.

But 74% said they did not have anxiety, and 83% said they didn’t have paranoia, which can occur with marijuana use."Delta-8 seems to have a better profile than delta-9," Daniel Kruger says. But, also, he says, states are loosening up on delta-9, and some are home made viagra tightening up on delta-8. Their data suggests that's backward, he says. Delta-8's Dark SideIn 2021, the FDA issued a consumer update, warning that delta-8 THC has serious health risks. Reports from December 2020 through July 2021 involved 22 people, some of whom reported vomiting, home made viagra hallucinations, trouble standing, and passing out after consuming delta-8 THC products.In September 2021, the CDC issued an alert about delta-8 and possible adverse events.

In the first half of 2021, the National Poison Data System recorded 660 exposures to delta-8 (and added another from late 2020), with 18%, or 119, requiring hospitalization and 39%, or 258, affecting children. It also warned that the products may not be tested well for contaminants like heavy metals and pesticides home made viagra. Mislabeling is also an issue. In an independent analysis of 51 products, home made viagra by CBD Oracle, a cannabis consumer research company, 77% had less delta-8 THC than advertised and three-quarters of the products had higher THC levels than permitted by federal law. The problems come back to a lack of regulation, Babalonis says.

The products are sold without adequate warning labels, and they are widely available. €œOnline, you can get a package of gummy bears, with beautiful packaging," she says, with home made viagra no mention that it's a drug. Delta-8 is especially hazardous for children, she says, and as dangerous as delta-9.“For children [who get into delta-8 products], they sometimes need to be intubated because they have ingested so much," Babalonis says. "Because they are not going to eat just home made viagra one gummy bear, right?. "Companies’ Safety EffortsSafety efforts, including efforts to avoid contamination, are ongoing, company representatives say.

The website of Your CBD Store, home made viagra which includes nearly 500 stores nationwide, includes lab reports, and the company walks viewers through how to read them. It posts warnings cautioning that the products may result in a positive drug test.It also says its delta-8 extract is “100 percent naturally derived from hemp and does not contain more than 0.3 percent delta-9 THC."At Bison Botanics, products are sent to an independent lab for testing, Connors says. On its website, the company also says people have different sensitivities to different cannabinoids, especially THC. Even though the amounts are low, it warns that everyone handles home made viagra these substances differently. Legislative EffortsConcerns about safety have triggered state actions, with legislators debating whether to prohibit delta-8 or regulate it.

As of late December, 14 states have made delta-8 illegal, according home made viagra to an industry website. It's legal in 30 other states, while it's regulated the same as recreational cannabis in Connecticut and Michigan.Moves to ban delta-8 are driven by fear, not science, Jessica Kruger says. More research is needed, she home made viagra and others say. €œOur study shows this may actually be a safer way to use cannabis."The U.S. Hemp Roundtable, an industry group, is not calling for a strict ban on delta-8 products, but it has taken a strong stance against the intoxicating forms of delta-8 -- home made viagra the ones that are over the approved 0.3 limit.

"From early last year, our position has been that intoxicating products should be treated akin to adult-use cannabis," says Jonathan S. Miller, the group’s general counsel.Beyond LegislationThe Krugers favor universal product testing and more regulation. Currently, "you can go to the home made viagra gas station and get [these products], which is terrifying," Jessica Kruger says. Ideally, Daniel Kruger says, he hopes for de-scheduling cannabis on a federal level, along with more regulation.“Education is key," Jessica Kruger says, especially for protecting vulnerable populations such as children and pregnant women.By Alan Mozes HealthDay ReporterMONDAY, Jan. 31, 2022 (HealthDay News) -- home made viagra The images are never-ending.

Celebrities like Kim Kardashian posting one suy shot after another on social media. But new research warns this constant barrage of "perfect" bodies can undermine the self-esteem of young women.They're apt to feel their own figures come up short by comparison --- whether those influencers and celebrities are super-thin, super-fit or super-curvy.And now it turns out that it's the so-called "slim-thick" look — exemplified by hourglass-figured beauties such as Beyoncé and Kim Kardashian — that's most likely to make today's woman feel bad about their own bodies.So finds an analysis that gauged body image dissatisfaction among 400 college undergrads who viewed Instagram images of models and influencers."The main take-away is home made viagra that comparing oneself to idealized images on Instagram is harmful for women's body image," explained study author Sarah McComb, a clinical psychology Ph.D. Candidate at York University in Toronto."We found that, overall, women who compared themselves to one of the three body types on Instagram experienced increased weight dissatisfaction, appearance dissatisfaction, and lower overall body satisfaction than those... Who saw home décor images," McComb noted. Those types included rail "thin" like a home made viagra runway model.

Impossibly "fit" like an Olympic athlete. Or hourglass "slim-thick" figures like Kim Kardashian.Viewing images of any of the three body types did a number on the women enrolled in the study, home made viagra McComb said, undermining a young woman's confidence to some degree across the board.But it was images featuring women more in the mold of a slim-thick type -- tiny waist, large derriere -- that seemed to prompt relatively greater levels of body dissatisfaction, she added."Beauty ideals can certainly shift over time," McComb observed. "For a long time, very thin and slender bodies have predominated Western media. However, more recently other body types have gained popularity in mainstream media, such as the fit ideal, which home made viagra is characterized by a more toned and athletic body type. And the slim-thick ideal, which is perhaps even more recent."The rise of the latter, she noted, likely reflects the enormous popularity of household names like Kardashian and Kylie Jenner, and the high-profile marketing of "a female body type that is characterized by a small waist and flat stomach, but large thighs, hips and buttocks." Viewing images of this idealized body type seemed to trigger the greatest degree of body dissatisfaction, the study revealed, which "suggests that the slim-thick ideal is not a healthier body ideal than the thin-ideal, even though the slim-thick ideal is a larger body type," said McComb."These images often depict bodies that are nearly impossible to obtain naturally, or which have been highly edited unbeknownst to the viewer," she noted.

"[And] while comparison on social media may not cause eating disorders in isolation, it can be a contributor to disordered eating and poor body image among those who are already vulnerable."The report was published in the March issue of the journal Body Image.It's a big concern, agreed Chelsea Kronengold, associate director of communications for the National Eating Disorders Association (NEDA)."In recent years, media and societal messages have deemed a 'slim-thick' body as the ideal body," Kronengold noted. "So it is understandable that people with a different body shape experienced increased dissatisfaction with their body and appearance, especially after looking at and/or comparing themselves to slim-thick imagery." But "people often forget that celebrities and public figures typically have home made viagra a beauty team of hairdressers, makeup artists and stylists," Kronengold stressed. "Likewise, plastic surgery and the use of digital editing apps or social media filters can create an unrealistic perception of beauty and harmful social comparison, particularly when the folks looking at these pictures are unaware of physical or digital alterations."Lona Sandon, program director of the department of clinical nutrition at UT Southwestern Medical Center in Dallas, said she thinks "most women know it is impossible to achieve such a look in a natural and healthy way, or without restrictive body shaping attire under their clothing."But "this can be a very disappointing reality leading to high dissatisfaction, as one has very limited control over their overall body shape," she added.And the risk is that with time, disappointment and dissatisfaction may slide into depression, isolation, low self-esteem, and ultimately an obsession with weight loss that can develop into eating disorders such as anorexia nervosa or bulimia, Kronengold explained. NEDA estimates that some 30 million Americans will struggle with eating disorders at some point in their lives, though Sandon noted that the numbers shot up about 5% between 2000 and 2018.In fact, Sandon said she thinks home made viagra it's highly likely that even more women silently struggle with an eating disorder "as a result of images they see."More informationThere's more on how to get help addressing body image struggles and eating disorders at NEDA.SOURCES. Sarah McComb, MA, PhD candidate, clinical psychology, faculty of health department of psychology, York University, Toronto, Ontario, Canada.

Lona Sandon, PhD, RDN, LD, program director and associate professor, home made viagra department of clinical nutrition, school of health professions, UT Southwestern Medical Center, Dallas. Chelsea Kronengold, associate director, communications, National Eating Disorders Association. Body Image, March 2022By Rae Ellen Bichell Monday, January 31, 2022 (Kaiser News) -- What does it mean if a person’s rapid antigen test result comes back positive after five days of isolation due to erectile dysfunction treatment?. According to the experts, that person is most likely still carrying a viral load high enough to infect others home made viagra. €œAnytime you’re positive by one of these rapid at-home erectile dysfunction treatment tests, it means that you’ve still got a really high level of the viral protein, and most experts are interpreting that as a high level of viagra present in your nasal passage,” said Matthew Binnicker, director of clinical virology at the Mayo Clinic and president of the Pan American Society for Clinical Virology.

The Biden administration is buying a billion rapid home made viagra antigen tests to ship to American homes, aiming to address the need for increased erectile dysfunction treatment testing and ease a nationwide shortage of tests. That influx of tests comes on the heels of revised federal guidelines that shortened the isolation period to five days after symptoms started or a positive test, followed by five days of masking. It’s widely known that PCR tests, the highly sensitive polymerase chain reaction tests that detect viral genetic material, can pick up “dead” viagra — material not capable of replicating — and yield a positive result for weeks after recovery, even when the home made viagra person being tested is no longer infectious. But virologists say that’s unlikely to be the case for the rapid antigen tests — which detect certain proteins in the viagra and produce results within 30 minutes — that are headed for people’s mailboxes. The odds are very slim, outside of home made viagra a laboratory setting, that someone who gets a positive result on a rapid antigen test is a non-infectious person shedding large amounts of dead viagra, said Kelly Wroblewski, director of infectious disease programs for the Association of Public Health Laboratories.

There are several reasons for this. First, according to the Infectious Diseases Society of America, “a major advantage” of rapid antigen tests is that they are somewhat blunt tools for picking up on the viagra. Therefore, a positive result tends to mean the person has a high viral load, especially if symptoms home made viagra appeared. Continued Second, it takes a substantial amount of viagra material to register as positive on an antigen test, so a person would need a high level of dead viagra sitting around in their nose or throat, and usually that signals a high level of live viagra, too. Third, even if someone did have a high level of home made viagra dead viagra hanging around, quantity alone wouldn’t be enough to trigger a positive test — viral proteins tend to lose their shape after a battle with the immune system, which can render them undetectable by antigen tests.

In a laboratory setting, a rapid antigen test could detect bits of “dead” viagra, said Dr. Sam Dominguez, a pediatric infectious disease doctor home made viagra and the medical director of the clinical microbiology lab at Children’s Hospital Colorado. Federally funded scientists did just that to check whether rapid antigen tests would work as well on omicron as they did on other erectile dysfunction treatment variants. However, Dominguez said, the odds of dead viagra — and dead viagra alone — triggering a positive antigen test in a human rather than a petri dish are low. Unlike scientists in a lab, the human body in attack mode isn’t trying to inactivate viagraes just home made viagra so.

It’s trying to obliterate them, proteins and all. €œRNA can last longer than the proteins,” said Wroblewski, but neither home made viagra substance is known for sturdiness. Even for scientists it’s somewhat of an art to keep proteins intact after inactivating the viagra. €œIt is not easy,” said home made viagra Dr. Izabela Ragan, a veterinary scientist at Colorado State University who has branched into human virology, and who has worked for about two years on developing a treatment against erectile dysfunction.

Her work hinges on killing the viagra while preserving the shape of its proteins. The confusion around how to interpret test results stems largely from home made viagra this conundrum. While there is a wealth of testing options available, there is no foolproof way to gauge whether a person is actually infectious. €œI wish there home made viagra was,” said Binnicker. €œThere is no test that we have for infectiousness.” Continued The best option is to take a patient’s sample, stick it in a dish of thriving living cells, and see what happens to the healthy cells.

If there’s live viagra, said Dirk home made viagra Dittmer, a virologist at the University of North Carolina-Chapel Hill, “then the cells would die, just like the lung cells in your body would die.” But the finicky process takes about three days and can be done only in labs cleared to handle such pathogens, rendering it impractical. Instead, the most widely available tests rely on totally different methods. They fall into two categories, typically called molecular tests and antigen tests. Molecular tests, including PCR, look for specific bits of the home made viagra viagra’s RNA. With the exception of a few over-the-counter options, the tests are processed in a lab.

They are capable of detecting tiny bits and pieces of the viagra’s genetic material by copying whatever is floating around in home made viagra a person’s sample over and over, amplifying it “a million- to a trillion-fold,” said Dr. Marie Louise Landry, director of the Clinical Virology Laboratory at Yale New Haven Hospital. That’s why, she explained, “PCR can detect very low levels of viral RNA for weeks and even months after , when a patient is no longer infectious.” Rapid antigen tests, on the other hand, look for home made viagra viral proteins rather than the viagra’s genetic material. Many of them look for nucleocapsid or “N” proteins, which are abundant in infected cells and form a protective capsule around the viagra’s genetic material. Unlike molecular tests, rapid antigen tests work only with home made viagra what’s available — no copying or amplifying involved.

These tests drag a person’s sample across a special piece of paper that contains a fence of antibodies designed to grab onto the viagra’s N proteins. If enough proteins snag on the fence, a visible line of color will appear. €œEven single molecules can turn a PCR positive,” home made viagra said Dr. Michael Mina, an epidemiologist who has been a vocal supporter of rapid testing throughout the viagra and is now chief science officer for the health care company eMed. But, he added, it takes “about 100,000-1,000,000 molecules to turn the rapid antigen test positive.” Continued But what about the official home made viagra recommendation that people with erectile dysfunction treatment should isolate for five days at home — followed by five days of masking?.

Data from the world of sports, where resources and testing methods abound, offer a glimpse into how variable that period of infectiousness might be. A preliminary study of NBA home made viagra players and employees found that among 70 people infected with omicron, by Day 5 after their first positive test about 40% of them were still likely infectious. €œWhat we’re recommending is that between Days 5 and 10, you can take an antigen test. If it’s positive, you stay in isolation till Day 10,” said Binnicker. CDC public affairs specialist Jasmine Reed said the best home made viagra approach is to use an antigen test toward the end of the five-day isolation period if the person’s symptoms have improved.

€œIf your test result is positive, you should continue to isolate until Day 10,” she said. Wroblewski said an home made viagra important gauge of contagiousness is the simplest. How someone is feeling. €œIf you have a high fever and home made viagra a cough, don’t go see people. I feel like we somehow forgot that part,” she said.

€œLet’s not put so much emphasis on the test and the technology that we forget basic control practices. That if you’re sick, stay home.” KHN (Kaiser Health News) is a national newsroom that produces in-depth home made viagra journalism about health issues. Together with Policy Analysis and Polling, KHN is one of the three major operating programs at KFF (Kaiser Family Foundation). KFF is home made viagra an endowed nonprofit organization providing information on health issues to the nation. USE OUR CONTENT This story can be republished for free (details).

WebMD News from Kaiser Health News ©2013-2022 Henry J. Kaiser Family Foundation. All rights reserved..

Jan. 31, 2022 -- This past October, Chris Habitz, the owner of Your CBD Store in Burbank, CA, began getting more requests from customers for CBD products with delta -8 THC, also known as "diet weed" or "marijuana-lite."Many were seniors, he says, asking for the products to soothe pain and avoid opioids, as well as to avoid the high" from using marijuana.Citing the potential for addiction to prescription painkillers, Habitz says, "a lot them are scared."Others asked for the delta-8 products to soothe anxiety during the viagra. So, Habitz ordered three times as many of the delta-8 products as usual -- and sold them.

The demand has remained. And, he says, “it hasn't peaked."On the other side of the country, Bison Botanics in Buffalo, NY, which sells a range of CBD products, began seeing high demand for delta-8 products at the start of 2021, says Sean Connors, Bison's vice president. "By the end of 2021, it was 65% of sales," he says.

Delta-8 THC (tetrahydrocannabinol) is one of more than 100 compounds, or cannabinoids, found in the Cannabis sativa plant. Delta-8 is found in marijuana and in hemp-derived CBD, but in trace amounts, much lower than the levels of delta-9 THC found in marijuana that produces the “high."Delta-8 THC products, sold in vape pen cartridges and as oils, gummies, candies, and other edibles, are widely available at CBD stores, convenience stores, gas stations, dispensaries, and online. Besides pain and anxiety relief, promoters say it can boost appetite, help you sleep better, combat nausea and vomiting, and help with relaxation.It's difficult to pinpoint nationwide sales figures, with many companies not reporting publicly, says Adam Koh, editorial director of Cannabis Benchmarks &.

Hemp Benchmarks, which provides industry data."I think it's safe to say that sales of delta-8 THC and similar products in the U.S. Likely generated several hundred million dollars in 2021. These products began to emerge around summer 2020, and I believe sales were substantially smaller that year."Online searches for delta-8 THC rose dramatically from 2019 to 2020, say researchers from the University of California, San Diego, who reported that interest was especially high in U.S.

States that restricted delta-9 THC use. Is It Legal, or Is There a Loophole?. No one debates delta-8 THC's popularity.

But is it legal?. As sales have risen, so have debates about its legality.The boom in delta-8 products began shortly after the passage of the Farm Bill, also known as the Agriculture Improvement Act of 2018. This act removed hemp and its byproducts (but not cannabis) from the federal list of Schedule I controlled substances.

It legalizes the production and sale of CBD products as long as they have less than 0.3% of THC. Many advocates of delta-8 CBD products point out that the Farm Bill fails to mention delta-8, so the products are on legal firm ground. Not everyone agrees."People read that Farm Bill and said, 'Wait, delta-8 and delta-10 [another cannabinoid] are not mentioned,'" says researcher Shanna Babalonis, PhD, an assistant professor of behavioral science at the University of Kentucky.

"Let's start marketing that stuff."Here's the problem, says Paul Armentano, deputy director of the National Organization for the Reform of Marijuana Laws, or NORML. The Farm Bill language does make a legal distinction between “naturally occurring constituents" and "synthetically derived" ones. He points to how the Drug Enforcement Administration defined the issue in the Farm Bill in 2020.

Under that explanation, "if you extract cannabinoids present in the industrial hemp plant, products from those are legal under the Farm Bill," he says.If delta-8 were simply extracted, fine. But "that is not what these [delta-8] products are."The natural amount of delta-8-THC in hemp is low, but concentrated amounts can be created from CBD in a lab. Large quantities of delta-8 THC “are being chemically synthesized from excess CBD that has been derived from hemp plants," Babalonis says.And all synthetic tetrahydrocannabinols are still Schedule I controlled substances, just as marijuana is, according to language in the Farm Bill, Armentano says.

The Farm Bill also specifies that hemp can't contain more than 0.3% of THC, and observers say many delta-8 products contain higher levels, making the products intoxicating.Delta-8. Nicer and Milder, or Potentially Hazardous?. While some debate whether delta-8 THC is legal, researchers say it has been called “delta-9's younger, nicer sibling." That's what one respondent told researchers Jessica Kruger, PhD, a clinical assistant professor of community health and health behavior at the University at Buffalo, and Daniel J.

Kruger, PhD, an investigator at the Population Studies Center at the University of Michigan. After the husband-wife research team polled more than 500 people from 38 states and asked them to compare delta-8 to cannabis, they concluded that delta-8 appears to have positive qualities and may be a way to reduce harm and negative reactions, compared to marijuana. Respondents said delta-8 THC had all the benefits of cannabis and fewer bad effects.In their study, 71% of the users reported “a lot or a great deal” of relaxation, and 68% said they’d had euphoria.

More than half got relief from pain. But they also reported some of the same unwanted effects with delta-8 as with marijuana, with 81% having moderate to “a lot of" skewed thinking, such as a hard time concentrating. But 74% said they did not have anxiety, and 83% said they didn’t have paranoia, which can occur with marijuana use."Delta-8 seems to have a better profile than delta-9," Daniel Kruger says.

But, also, he says, states are loosening up on delta-9, and some are tightening up on delta-8. Their data suggests that's backward, he says. Delta-8's Dark SideIn 2021, the FDA issued a consumer update, warning that delta-8 THC has serious health risks.

Reports from December 2020 through July 2021 involved 22 people, some of whom reported vomiting, hallucinations, trouble standing, and passing out after consuming delta-8 THC products.In September 2021, the CDC issued an alert about delta-8 and possible adverse events. In the first half of 2021, the National Poison Data System recorded 660 exposures to delta-8 (and added another from late 2020), with 18%, or 119, requiring hospitalization and 39%, or 258, affecting children. It also warned that the products may not be tested well for contaminants like heavy metals and pesticides.

Mislabeling is also an issue. In an independent analysis of 51 products, by CBD Oracle, a cannabis consumer research company, 77% had less delta-8 THC than advertised and three-quarters of the products had higher THC levels than permitted by federal law. The problems come back to a lack of regulation, Babalonis says.

The products are sold without adequate warning labels, and they are widely available. €œOnline, you can get a package of gummy bears, with beautiful packaging," she says, with no mention that it's a drug. Delta-8 is especially hazardous for children, she says, and as dangerous as delta-9.“For children [who get into delta-8 products], they sometimes need to be intubated because they have ingested so much," Babalonis says.

"Because they are not going to eat just one gummy bear, right?. "Companies’ Safety EffortsSafety efforts, including efforts to avoid contamination, are ongoing, company representatives say. The website of Your CBD Store, which includes nearly 500 stores nationwide, includes lab reports, and the company walks viewers through how to read them.

It posts warnings cautioning that the products may result in a positive drug test.It also says its delta-8 extract is “100 percent naturally derived from hemp and does not contain more than 0.3 percent delta-9 THC."At Bison Botanics, products are sent to an independent lab for testing, Connors says. On its website, the company also says people have different sensitivities to different cannabinoids, especially THC. Even though the amounts are low, it warns that everyone handles these substances differently.

Legislative EffortsConcerns about safety have triggered state actions, with legislators debating whether to prohibit delta-8 or regulate it. As of late December, 14 states have made delta-8 illegal, according to an industry website. It's legal in 30 other states, while it's regulated the same as recreational cannabis in Connecticut and Michigan.Moves to ban delta-8 are driven by fear, not science, Jessica Kruger says.

More research is needed, she and others say. €œOur study shows this may actually be a safer way to use cannabis."The U.S. Hemp Roundtable, an industry group, is not calling for a strict ban on delta-8 products, but it has taken a strong stance against the intoxicating forms of delta-8 -- the ones that are over the approved 0.3 limit.

"From early last year, our position has been that intoxicating products should be treated akin to adult-use cannabis," says Jonathan S. Miller, the group’s general counsel.Beyond LegislationThe Krugers favor universal product testing and more regulation. Currently, "you can go to the gas station and get [these products], which is terrifying," Jessica Kruger says.

Ideally, Daniel Kruger says, he hopes for de-scheduling cannabis on a federal level, along with more regulation.“Education is key," Jessica Kruger says, especially for protecting vulnerable populations such as children and pregnant women.By Alan Mozes HealthDay ReporterMONDAY, Jan. 31, 2022 (HealthDay News) -- The images are never-ending. Celebrities like Kim Kardashian posting one suy shot after another on social media.

But new research warns this constant barrage of "perfect" bodies can undermine the self-esteem of young women.They're apt to feel their own figures come up short by comparison --- whether those influencers and celebrities are super-thin, super-fit or super-curvy.And now it turns out that it's the so-called "slim-thick" look — exemplified by hourglass-figured beauties such as Beyoncé and Kim Kardashian — that's most likely to make today's woman feel bad about their own bodies.So finds an analysis that gauged body image dissatisfaction among 400 college undergrads who viewed Instagram images of models and influencers."The main take-away is that comparing oneself to idealized images on Instagram is harmful for women's body image," explained study author Sarah McComb, a clinical psychology Ph.D. Candidate at York University in Toronto."We found that, overall, women who compared themselves to one of the three body types on Instagram experienced increased weight dissatisfaction, appearance dissatisfaction, and lower overall body satisfaction than those... Who saw home décor images," McComb noted.

Those types included rail "thin" like a runway model. Impossibly "fit" like an Olympic athlete. Or hourglass "slim-thick" figures like Kim Kardashian.Viewing images of any of the three body types did a number on the women enrolled in the study, McComb said, undermining a young woman's confidence to some degree across the board.But it was images featuring women more in the mold of a slim-thick type -- tiny waist, large derriere -- that seemed to prompt relatively greater levels of body dissatisfaction, she added."Beauty ideals can certainly shift over time," McComb observed.

"For a long time, very thin and slender bodies have predominated Western media. However, more recently other body types have gained popularity in mainstream media, such as the fit ideal, which is characterized by a more toned and athletic body type. And the slim-thick ideal, which is perhaps even more recent."The rise of the latter, she noted, likely reflects the enormous popularity of household names like Kardashian and Kylie Jenner, and the high-profile marketing of "a female body type that is characterized by a small waist and flat stomach, but large thighs, hips and buttocks." Viewing images of this idealized body type seemed to trigger the greatest degree of body dissatisfaction, the study revealed, which "suggests that the slim-thick ideal is not a healthier body ideal than the thin-ideal, even though the slim-thick ideal is a larger body type," said McComb."These images often depict bodies that are nearly impossible to obtain naturally, or which have been highly edited unbeknownst to the viewer," she noted.

"[And] while comparison on social media may not cause eating disorders in isolation, it can be a contributor to disordered eating and poor body image among those who are already vulnerable."The report was published in the March issue of the journal Body Image.It's a big concern, agreed Chelsea Kronengold, associate director of communications for the National Eating Disorders Association (NEDA)."In recent years, media and societal messages have deemed a 'slim-thick' body as the ideal body," Kronengold noted. "So it is understandable that people with a different body shape experienced increased dissatisfaction with their body and appearance, especially after looking at and/or comparing themselves to slim-thick imagery." But "people often forget that celebrities and public figures typically have a beauty team of hairdressers, makeup artists and stylists," Kronengold stressed. "Likewise, plastic surgery and the use of digital editing apps or social media filters can create an unrealistic perception of beauty and harmful social comparison, particularly when the folks looking at these pictures are unaware of physical or digital alterations."Lona Sandon, program director of the department of clinical nutrition at UT Southwestern Medical Center in Dallas, said she thinks "most women know it is impossible to achieve such a look in a natural and healthy way, or without restrictive body shaping attire under their clothing."But "this can be a very disappointing reality leading to high dissatisfaction, as one has very limited control over their overall body shape," she added.And the risk is that with time, disappointment and dissatisfaction may slide into depression, isolation, low self-esteem, and ultimately an obsession with weight loss that can develop into eating disorders such as anorexia nervosa or bulimia, Kronengold explained.

NEDA estimates that some 30 million Americans will struggle with eating disorders at some point in their lives, though Sandon noted that the numbers shot up about 5% between 2000 and 2018.In fact, Sandon said she thinks it's highly likely that even more women silently struggle with an eating disorder "as a result of images they see."More informationThere's more on how to get help addressing body image struggles and eating disorders at NEDA.SOURCES. Sarah McComb, MA, PhD candidate, clinical psychology, faculty of health department of psychology, York University, Toronto, Ontario, Canada. Lona Sandon, PhD, RDN, LD, program director and associate professor, department of clinical nutrition, school of health professions, UT Southwestern Medical Center, Dallas.

Chelsea Kronengold, associate director, communications, National Eating Disorders Association. Body Image, March 2022By Rae Ellen Bichell Monday, January 31, 2022 (Kaiser News) -- What does it mean if a person’s rapid antigen test result comes back positive after five days of isolation due to erectile dysfunction treatment?. According to the experts, that person is most likely still carrying a viral load high enough to infect others.

€œAnytime you’re positive by one of these rapid at-home erectile dysfunction treatment tests, it means that you’ve still got a really high level of the viral protein, and most experts are interpreting that as a high level of viagra present in your nasal passage,” said Matthew Binnicker, director of clinical virology at the Mayo Clinic and president of the Pan American Society for Clinical Virology. The Biden administration is buying a billion rapid antigen tests to ship to American homes, aiming to address the need for increased erectile dysfunction treatment testing and ease a nationwide shortage of tests. That influx of tests comes on the heels of revised federal guidelines that shortened the isolation period to five days after symptoms started or a positive test, followed by five days of masking.

It’s widely known that PCR tests, the highly sensitive polymerase chain reaction tests that detect viral genetic material, can pick up “dead” viagra — material not capable of replicating — and yield a positive result for weeks after recovery, even when the person being tested is no longer infectious. But virologists say that’s unlikely to be the case for the rapid antigen tests — which detect certain proteins in the viagra and produce results within 30 minutes — that are headed for people’s mailboxes. The odds are very slim, outside of a laboratory setting, that someone who gets a positive result on a rapid antigen test is a non-infectious person shedding large amounts of dead viagra, said Kelly Wroblewski, director of infectious disease programs for the Association of Public Health Laboratories.

There are several reasons for this. First, according to the Infectious Diseases Society of America, “a major advantage” of rapid antigen tests is that they are somewhat blunt tools for picking up on the viagra. Therefore, a positive result tends to mean the person has a high viral load, especially if symptoms appeared.

Continued Second, it takes a substantial amount of viagra material to register as positive on an antigen test, so a person would need a high level of dead viagra sitting around in their nose or throat, and usually that signals a high level of live viagra, too. Third, even if someone did have a high level of dead viagra hanging around, quantity alone wouldn’t be enough to trigger a positive test — viral proteins tend to lose their shape after a battle with the immune system, which can render them undetectable by antigen tests. In a laboratory setting, a rapid antigen test could detect bits of “dead” viagra, said Dr.

Sam Dominguez, a pediatric infectious disease doctor and the medical director of the clinical microbiology lab at Children’s Hospital Colorado. Federally funded scientists did just that to check whether rapid antigen tests would work as well on omicron as they did on other erectile dysfunction treatment variants. However, Dominguez said, the odds of dead viagra — and dead viagra alone — triggering a positive antigen test in a human rather than a petri dish are low.

Unlike scientists in a lab, the human body in attack mode isn’t trying to inactivate viagraes just so. It’s trying to obliterate them, proteins and all. €œRNA can last longer than the proteins,” said Wroblewski, but neither substance is known for sturdiness.

Even for scientists it’s somewhat of an art to keep proteins intact after inactivating the viagra. €œIt is not easy,” said Dr. Izabela Ragan, a veterinary scientist at Colorado State University who has branched into human virology, and who has worked for about two years on developing a treatment against erectile dysfunction.

Her work hinges on killing the viagra while preserving the shape of its proteins. The confusion around how to interpret test results stems largely from this conundrum. While there is a wealth of testing options available, there is no foolproof way to gauge whether a person is actually infectious.

€œI wish there was,” said Binnicker. €œThere is no test that we have for infectiousness.” Continued The best option is to take a patient’s sample, stick it in a dish of thriving living cells, and see what happens to the healthy cells. If there’s live viagra, said Dirk Dittmer, a virologist at the University of North Carolina-Chapel Hill, “then the cells would die, just like the lung cells in your body would die.” But the finicky process takes about three days and can be done only in labs cleared to handle such pathogens, rendering it impractical.

Instead, the most widely available tests rely on totally different methods. They fall into two categories, typically called molecular tests and antigen tests. Molecular tests, including PCR, look for specific bits of the viagra’s RNA.

With the exception of a few over-the-counter options, the tests are processed in a lab. They are capable of detecting tiny bits and pieces of the viagra’s genetic material by copying whatever is floating around in a person’s sample over and over, amplifying it “a million- to a trillion-fold,” said Dr. Marie Louise Landry, director of the Clinical Virology Laboratory at Yale New Haven Hospital.

That’s why, she explained, “PCR can detect very low levels of viral RNA for weeks and even months after , when a patient is no longer infectious.” Rapid antigen tests, on the other hand, look for viral proteins rather than the viagra’s genetic material. Many of them look for nucleocapsid or “N” proteins, which are abundant in infected cells and form a protective capsule around the viagra’s genetic material. Unlike molecular tests, rapid antigen tests work only with what’s available — no copying or amplifying involved.

These tests drag a person’s sample across a special piece of paper that contains a fence of antibodies designed to grab onto the viagra’s N proteins. If enough proteins snag on the fence, a visible line of color will appear. €œEven single molecules can turn a PCR positive,” said Dr.

Michael Mina, an epidemiologist who has been a vocal supporter of rapid testing throughout the viagra and is now chief science officer for the health care company eMed. But, he added, it takes “about 100,000-1,000,000 molecules to turn the rapid antigen test positive.” Continued But what about the official recommendation that people with erectile dysfunction treatment should isolate for five days at home — followed by five days of masking?. Data from the world of sports, where resources and testing methods abound, offer a glimpse into how variable that period of infectiousness might be.

A preliminary study of NBA players and employees found that among 70 people infected with omicron, by Day 5 after their first positive test about 40% of them were still likely infectious. €œWhat we’re recommending is that between Days 5 and 10, you can take an antigen test. If it’s positive, you stay in isolation till Day 10,” said Binnicker.

CDC public affairs specialist Jasmine Reed said the best approach is to use an antigen test toward the end of the five-day isolation period if the person’s symptoms have improved. €œIf your test result is positive, you should continue to isolate until Day 10,” she said. Wroblewski said an important gauge of contagiousness is the simplest.

How someone is feeling. €œIf you have a high fever and a cough, don’t go see people. I feel like we somehow forgot that part,” she said.

€œLet’s not put so much emphasis on the test and the technology that we forget basic control practices. That if you’re sick, stay home.” KHN (Kaiser Health News) is a national newsroom that produces in-depth journalism about health issues. Together with Policy Analysis and Polling, KHN is one of the three major operating programs at KFF (Kaiser Family Foundation).

KFF is an endowed nonprofit organization providing information on health issues to the nation. USE OUR CONTENT This story can be republished for free (details). WebMD News from Kaiser Health News ©2013-2022 Henry J.

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